Methyl 3,5-Diamino-6-chloropyrazine-2-carboxylate

Methyl 3,5-Diamino-6-chloropyrazine-2-carboxylate - Names and Identifiers

Name	3,5-DIAMINO-6-CHLORO-PYRAZINE-2-CARBOXYLIC ACID METHYL ESTER
Synonyms	AmiloriderelatedcompoundA 3,5-diamino-6-chloro-pyrazin methyl ester Methyl 3,5-diamino-6-chloropyrazinecarboxylate methyl 3,5-diamino-6-chloropyrazinecarboxylate METHYL3,5-DIAMINO-6-CHLOROPYRAZINE-2-CARBOXVLATE METHYL 3,5-DIAMINO-6-CHLOROPYRAZINE-2-CARBOXYLATE Methyl 3,5-diamino-6-chloropyrazine-2-carboxylate METHYL-6-CHLORO-3,5-DIAMINO PYRAZINE -2-CARBOXYLATE methyl 3,5-bis(azanyl)-6-chloro-pyrazine-2-carboxylate 3,5-DIAMINO-6-CHLORO-PYRAZINE-2-CARBOXYLIC ACID METHYL ESTER
CAS	1458-01-1
EINECS	215-946-1
InChI	InChI=1/C6H7ClN4O2/c1-13-6(12)2-4(8)11-5(9)3(7)10-2/h1H3,(H4,8,9,11)
InChIKey	KOOBYHRLTYIPTH-UHFFFAOYSA-N

Methyl 3,5-Diamino-6-chloropyrazine-2-carboxylate - Physico-chemical Properties

Molecular Formula	C6H7ClN4O2
Molar Mass	202.6
Density	1.555±0.06 g/cm3(Predicted)
Melting Point	211-215 °C (lit.)
Boling Point	449.9±40.0 °C(Predicted)
Flash Point	225.9°C
Solubility	DMSO (Slightly), Methanol (Slightly, Sonicated)
Vapor Presure	2.75E-08mmHg at 25°C
Appearance	Crystalline powder
Color	Light Brown to Brown
pKa	-0.10±0.10(Predicted)
Storage Condition	Keep in dark place,Inert atmosphere,2-8°C
Stability	Stable. Incompatible with strong oxidizing agents.
Refractive Index	1.65
MDL	MFCD01928388

Methyl 3,5-Diamino-6-chloropyrazine-2-carboxylate - Risk and Safety

Hazard Symbols	Xi - Irritant
Risk Codes	36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37 - Wear suitable protective clothing and gloves.
WGK Germany	3
HS Code	2933997500

Methyl 3,5-Diamino-6-chloropyrazine-2-carboxylate - Reference Information

introduction

3, 5-diamino-6-chlorpyrazine-2-carboxylate methyl ester is a pharmaceutical intermediate, and it has been reported in the literature that it can be used to prepare ENaC inhibitors and compounds for the treatment of cystic fibrosis.

Application

3, 5-diamino-6-chlorpyrazine-2-carboxylic acid methyl ester can be used to prepare the following benzodiazolium compound. Compounds of alternative structures of 6-halogenated -3, 5-diaminopyrazine or 6-substituted-3-aminopyrazine also have ENaC blocking activity and may have beneficial properties compared to known compounds, especially those related to ADME (absorption, excretion, distribution and metabolism).

Last Update：2024-04-09 19:05:10